So, in desperation, many of us completely uninstall and reinstall the software, if we want to start afresh. Fortunately this doesn't take very long. BUT ... what the heck?? The settings are still there! Well, they were still there on my PC, anyway.
This drove me crazy until I figured out the solution. It's not enough to uninstall the software in the usual way, through the Programs control panel. After you've done that, you have to go to your AppData folder ...
C:\Users\[your computer name]\AppData\Local\
... and completely delete the Datacolor folder.
Then you can re-install the software, and it'll be back to the program default settings. You can happily commence calibrating, per my instructions here.